Advances in Radio Science www.adv-radio-sci.net 1684-9965 1684-9973 3 Kleinheubacher Berichte 2004 2005 10.5194/ars-3-39-2005 http://www.adv-radio-sci.net/3/39/2005/ http://www.adv-radio-sci.net/3/39/2005/ars-3-39-2005.html http://www.adv-radio-sci.net/3/39/2005/ars-3-39-2005.pdf 39 49 2005-05-12 Electro-Quasistatic Simulations in Bio-Systems Engineering and Medical Engineering U. van Rienen J. Flehr U. Schreiber S. Schulze U. Gimsa W. Baumann D. G. Weiss J. Gimsa R. Benecke H.-W. Pau Rostock University, Faculty of Computer Science and Electrical Engineering, Albert-Einstein-Str. 2, 18051 Rostock, Germany Rostock University, Faculty of Mathematics and Natural Sciences, Albert-Einstein-Str. 3, 18051 Rostock, Germany Rostock University, Faculty of Medicine, PF 10 08 88, 18055 Rostock, Germany Slowly varying electromagnetic fields play a key role in various applications in bio-systems and medical engineering. Examples are the electric activity of neurons on neurochips used as biosensors, the stimulating electric fields of implanted electrodes used for deep brain stimulation in patients with Morbus Parkinson and the stimulation of the auditory nerves in deaf patients, respectively. In order to simulate the neuronal activity on a chip it is necessary to couple Maxwell's and Hodgkin-Huxley's equations. First numerical results for a neuron coupling to a single electrode are presented. They show a promising qualitative agreement with the experimentally recorded signals. Further, simulations are presented on electrodes for deep brain stimulation in animal experiments where the question of electrode ageing and energy deposition in the surrounding tissue are of major interest. As a last example, electric simulations for a simple cochlea model are presented comparing the field in the skull bones for different electrode types and stimulations in different positions.